Many young people face a lack of confidence and embarrassment due to their skin being badly affected by acne and pimples. This disease (acne vulgaris) is most common in adolescence, although many cases continue into adulthood. Bad cases of acne can lead to permanent scarring, and often sufferers may also suffer from psychological ill effects, such as low self-esteem, which can lead to depressive illness and possibly even suicide. Medical treatments include topical treatments such as benzoyl peroxide, antibiotics, and isoretonin, which can be used for more severe cases. Some may however prefer a natural acne cure: aloe vera and melaleuca oil may be effective.