According to Henry Lardy, PhD, of the National Academy of Sciences, 7-KETO DHEA offers the benefits of DHEA without the associated risks. 7-KETO DHEA is a natural metabolite of DHEA. Once DHEA is converted to the 7-KETO form it can no longer be used to make the sex hormones that present cancer risks.
In preliminary studies on animals, 7-Keto DHEA stimulates the immune system, prevents muscle loss ,reduces stress, increases the calorie-burning rate by activating thermogenic liver enzymes and improves memory more than DHEA or a placebo. We will show you how 7-Keto DHEA can be used to help you quickly lose weight.
7-Keto DHEA is a metabolite of DHEA. It is a steroidal hormone that was discovered in the 1950s but received little research attention until the 1990s. Henry Lardy and his colleagues at the University of Wisconsin are studying this and related compounds for use in weight reduction, memory enhancement, immune system improvement, and skin integrity improvement.
The term 7-Keto DHEA is the brand name for the chemical compound 3-acetyl-7-oxo-dehydroepiandros-terone, a naturally occurring metabolite primarily produced in the adrenal glands and skin . This compound was first discovered in 1958, when it was isolated in urine.
Blood levels of 7-Keto follow the same course over time as DHEA, rising until about the age twenty and then slowly descends beginning around the age of thirty. Urinary excretion studies show that average blood concentrations of 7-Keto decline nearly 50% by age 50.
“This reduction in 7-Keto levels is partially responsible for the increases in body fat and total body weight often seen in older people,” notes Dr. Sergey Dzugan, president of Life Extension Scientific Information, Inc. “This decline also plays a role in the weakened immune function that is indicative of the aging process. Moreover, since DHEA and 7-Keto DHEA levels decline more rapidly than cortisol, this creates a period of cortisol dominance that can wreak havoc on the immune system, since cortisol is known as an immune system depressant. For these reasons, supplementation with 7-Keto is often recommended.”
7-Keto DHEA produces fat reduction through the process of thermogenesis. This term refers to heat creation. Increased levels of thermogenesis causes the metabolic rate to be elevated, which results in the conversion of stored fat into energy.
7-Keto DHEA increases the activity of thermogenic enzymes that stimulate the oxidation of fatty acids in the liver. These thermogenic enhancing enzymes are fatty acyl CoA oxidase, malic enzyme, and glycerol-3-phosphate dehydrogenase.6,10-12. These enzymes drive the liver cells to burn fatty acids for energy, which causes a lowering of triglycerides in the liver.
Supplementation with 7-Keto has a dramatic effect on boosting levels of these thermogenic-enhancing enzymes. A study published in Current Therapeutic Research revealed just how effective 7-Keto is in inducing rapid weight loss. In this randomized, double-blind, placebo-controlled study, 30 overweight adults (28 women and 2 men) were divided into two groups. Group 1 took 100 mg of 7-Keto twice a day for eight weeks, and group 2 took a matching placebo capsule. All subjects participated in an exercise program three times a week that consisted of 50 minutes of aerobic and non-aerobic cross training under the supervision of an exercise physiologist. Additionally, each subject was instructed to follow an 1800-calorie per day diet. The subjects underwent testing for blood chemistry, body composition, blood pressure, and dietary analysis at baseline and at weeks four and eight.
The researchers found that the 7-Keto group lost a significant amount of body weight compared to the placebo group. 6.3 versus 2.1 pounds. The 7-Keto group also lost a greater percentage of body fat compared to the placebo group. 1.8% versus 0.57%. No adverse consequences were reported. The results show that 7-Keto can reduce body weight and body fat when combined with exercise and a low calorie diet. This is caused by increased levels of fat burning enzymes in the liver with the addition of thyroid hormone elevation. These changes are known to boost basal metabolic rate, making it easier to lose excess pounds. Supplementation with 7-Keto DHEA can help to reverse the decline in metabolic rate that causes weight gain with increasing age. Unlike caffeine and ephedrine, 7-Keto does not have a central nervous system stimulating effect caused by nor-adrenalin release, nor does 7-Keto increase heart rate or blood pressure.
Aging is associated with a decline in immune system response. This leads to increased susceptibility to infections. A clinical research study at the Minnesota Applied Research Center in Minneapolis Minnesota found that four weeks of 7-Keto DHEA supplementation improved immune function in elderly patients. In this randomized, double-blind, placebo controlled study, twenty two women and twenty men over the age of 65 took 100 mg of 7-Keto DHEA twice a day or a placebo. Patients in the 7-Keto group had a significant decrease in immune suppressor cells and a significant increase in immune helper cells. The scientists concluded that 7-Keto was well tolerated and had no serious adverse effects.
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